Impact of sample size on the performance of multiple-model pharmacokinetic simulations.
نویسندگان
چکیده
Monte Carlo simulations are increasingly used to predict pharmacokinetic variability of antimicrobials in a population. We investigated the sample size necessary to provide robust pharmacokinetic predictions. To obtain reasonably robust predictions, a nonparametric model derived from a sample population size of >/=50 appears to be necessary as the input information.
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 50 11 شماره
صفحات -
تاریخ انتشار 2006